On non-workout days you can take Creatine anytime. On workout days, you can take it 30 minutes before, during, or 30 minutes after your workout. If taken before and during your workout, it will provide you with an energy and strength boost (which is why it's commonly included in pre-workouts and intra-workouts). And when taken after workouts, creatine will speed up recovery and have a better effect at increasing muscle mass than when taken before workouts. That's why there's no "best time to take creatine" as it depends on the individual.
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